Our Products

Hyaluronic Acid Oligosaccharides

Description

Hyaluronic Acid (HA) is a glycosaminoglycan composed of an alternating sequence of β1,3 glucuronic acid (GlcA) and β1,4 N-acetylglucosamine (GlcNAc).

To place an order or request a quotation please email info@iduron.co.uk

Information

In its native state HA is normally present in the extracellular matrix as a high molecular weight, high viscosity polymer essential for maintenance tissue architecture, elasticity and hydration. However it also has other key functions including the regulation of cell behavior through specific interactions with cell surface receptors and extracellular proteins. HA binding to individual proteins commonly involves relatively short sequences in the HA polymer and there is considerable evidence that HA fragments generated in vivo have distinctive properties from the intact polymer.

Iduron offers a range of oligosaccharides produced by controlled endolyase scission of  purified, low endotoxin Hyaluronic Acid (Streptococcal species). The oligosaccharides are separated by high resolution gel filtration and purity assessed on an analytical Superdex S75 HPLC column (see Data Sheets for profiles).

Size range of oligosaccharides dp2 to dp 20

dp is degree of monosaccharide polyimerisation. dp2 is a disaccharide, dp4 is a tetrasaccharide etc.

General formula: ∆HexAβ1,3 – [GlcNAcβ1,4 GlcAβ1,3]n – GlcNAc
n = number of disaccharide units

∆HexA is the C4-C5 unsaturated hexuronic acid at the non-reducing end of the oligosaccharides produced by endolyase scission of the HA polymer. The C4-C5 double bond absorbs strongly at 232nm and can be used for monitoring the oligosaccharides in various separation systems.

New Products - Biotin and Flourescently Labelled HA Oligosaccharides

In addition our HA Oligos we supply three biotin- or fluorescence-labelled (FITC or Ruthenium Red) hyaluronic acid (HA) oligomers with average mol wts of approximately 2200 (dp22), 2800 (dp28) and 3400 (dp34). The oligomers are tagged at their reducing ends to minimise interference with cell or protein interactions. A short PEG spacer is introduced between the biotin and the HA to facilitate use in SPR analyses. HA-oligosaccharides listed above (dp4 - dp20) may be available as labelled derivatives (biotin or fluorescence); please inquire at info@iduron.co.uk

Product Catalog No Qty £
  1. Hyaluronic Acid Oligosaccharide
    Hyaluronic Acid Oligosaccharide dp2 HA02 1mg 160.00 Enquire Now
    Hyaluronic Acid Oligosaccharide dp4 HA04 1mg 110.00 Enquire Now
    Hyaluronic Acid Oligosaccharide dp6 HA06 1mg 110.00 Enquire Now
    Hyaluronic Acid Oligosaccharide dp8 HA08 1mg 110.00 Enquire Now
    Hyaluronic Acid Oligosaccharide dp10 HA10 1mg 110.00 Enquire Now
    Hyaluronic Acid Oligosaccharide dp12 HA12 1mg 130.00 Enquire Now
    Hyaluronic Acid Oligosaccharide dp14 HA14 1mg 130.00 Enquire Now
    Hyaluronic Acid Oligosaccharide dp16 HA16 1mg 130.00 Enquire Now
    Hyaluronic Acid Oligosaccharide dp18 HA18 1mg 130.00 Enquire Now
    Hyaluronic Acid Oligosaccharide dp20 HA20 1mg 130.00 Enquire Now
  2. Biotin and Flourescently Labelled Hyaluronic Acid Oligosaccharides
    Hyaluronic Acid Oligosaccharide dp22 HA22 1mg
    130.00 Enquire Now
    Biotin-Hyaluronic Acid Oligosaccharide dp22 Biotin-HA22 1mg
    170.00 Enquire Now
    FITC-Hyaluronic Acid Oligosaccharide dp22 FITC-HA22 1mg
    170.00 Enquire Now
    Ruthenium-Hyaluronic Acid Oligosaccharide dp22 Ruthenium-HA22 1mg
    220.00 Enquire Now
    Hyaluronic Acid Oligosaccharide dp28 HA28 1mg
    130.00 Enquire Now
    Biotin-Hyaluronic Acid Oligosaccharide dp28 Biotin-HA28 1mg
    170.00 Enquire Now
    FITC-Hyaluronic Acid Oligosaccharide dp28 FITC-HA28 1mg
    170.00 Enquire Now
    Ruthenium-Hyaluronic Acid Oligosaccharide dp28 Ruthenium-HA28 1mg
    220.00 Enquire Now
    Hyaluronic Acid Oligosaccharide dp32 Hyaluronic Acid Oligosaccharide dp32 1mg
    130.00 Enquire Now
    Biotin-Hyaluronic Acid Oligosaccharide dp32 Biotin-HA32 1mg
    170.00 Enquire Now
    FITC-Hyaluronic Acid Oligosaccharide dp32 FITC-HA32 1mg
    170.00 Enquire Now
    Ruthenium-Hyaluronic Acid Oligosaccharide dp32 Ruthenium-HA32 1mg
    220.00 Enquire Now

Get a Quote

Are you interested in a product? or you need some information? Don't hesitate to get in touch.

Enquire