Our Products

Heparin Oligosaccharides and Desulphated Heparin Oligosaccharides

Prepared from high grade porcine heparin and desulphated heparins using bacterial Heparinase and isolated by high resolution gel filtration.

Heparin Oligosaccharides

Prepared by controlled partial depolymerisation of UF heparin by Heparinase I and separation of the derived oligosaccharides using high resolution gel filtration. The products cover the entire range of oligosaccharides present in Low Molecular Weight Heparins. 

General formula: *UA,2S – (GlcNS,6S – IdoA,2S) – GlcNS,6S

*the uronic acid at the non-reducing end of the chain contains a C4-C5 double bond due to the endolytic action of Heparinase I

Although the main disaccharide in heparin is the trisulphated unit GlcNS,6S – IdoA,2S heparin also contains di-, mono- and non-sulphated units; thus each size class of oligosaccharide, though substantially homogeneous in molecular size, contains structures that vary in content and pattern of sulphation. The 2mg amounts of supplied material can be subfractionated (eg. by SAX-hplc) for further analysis of naturally-occurring heparin sequences within a specific size class or classes. 

dp = degree of polymerisation where ‘n’ is the number of monosaccharides. So a dp4 (HO04) is a tetrasaccharide, a dp6 (HO06) is a hexasaccharide, a dp8 (HO08)is a octasaccharide………etc.

Main Heparin Disaccharide Unit

heparin-oligosaccharide-disacc-unit.gif#asset:1663:url

*the uronic acid at the non-reducing end of the chain contains a C4-C5 double bond due to the endolytic action of Heparinase 

Desulphated Heparin Oligosaccharides

Use to investiget the specific protein binding motifs in Heparin and HS GAGs. Use these products in conjunction with our heparin oligosaccharides and HepMers to investigate the essential functional groups and specific oligosaccharide chain length required for high affinity/optimal protein interactions.

4 variations of selectively desulphated heparin oligosaccharides are available, dp4 – dp12:

2-O-desulphated heparin oligosaccharides Sulphate group removed from the C2 of iduronate

6-O-desulphated heparin oligosaccharides Sulphate group removed from the C6 of glucosamine

N-desulphated heparin oligosaccharides Sulphate group removed from the N sulphate of the glucoasmine

N-desulphated re N-acetylated heparin oligosaccharides The free amino group (NH+3) in N-desulphated heparin has been modified by acetylation

Product Catalog No Qty £
  1. Heparin Oligosaccharides
    Heparin Oligosaccharide dp4 HO04 2mg 205.00 Enquire Now
    Heparin Oligosaccharide dp6 HO06 2mg 205.00 Enquire Now
    Heparin Oligosaccharide dp8 HO08 2mg 205.00 Enquire Now
    Heparin Oligosaccharide dp10 HO10 2mg 205.00 Enquire Now
    Heparin Oligosaccharide dp12 HO12 2mg 205.00 Enquire Now
    Heparin Oligosaccharide dp14 HO14 2mg 205.00 Enquire Now
    Heparin Oligosaccharide dp16 HO16 2mg 205.00 Enquire Now
    Heparin Oligosaccharide dp18 HO18 2mg 205.00 Enquire Now
    Heparin Oligosaccharide dp20 HO20 2mg 205.00 Enquire Now
    Heparin Saccharide Av. Mol. Wt. 6300 HO22 2mg 205.00 Enquire Now
    Heparin Saccharide Av. Mol. Wt. 6850 HO24 2mg 205.00 Enquire Now
    Heparin Saccharide <9000 HO30 2mg 80 Enquire Now
  2. 2-O-desulphated Heparin Oligosaccharides
    2-O-Desulphated Heparin Oligo dp4 2-O DSHO04 1mg 125.00 Enquire Now
    2-O-Desulphated Heparin Oligo dp6 2-O DSHO06 1mg 125.00 Enquire Now
    2-O-Desulphated Heparin Oligo dp8 2-O DSHO08 1mg 125.00 Enquire Now
    2-O-Desulphated Heparin Oligo dp10 2-O DSHO10 1mg 125.00 Enquire Now
    2-O-Desulphated Heparin Oligo dp12 2-O DSHO12 1mg 125.00 Enquire Now
  3. 6-O-desulphated Heparin Oligosaccharides
    6-O-Desulphated Heparin Oligo dp4 6-O DSHO04 1mg 150.00 Enquire Now
    6-O-Desulphated Heparin Oligo dp6 6-O DSHO06 1mg 150.00 Enquire Now
    6-O-Desulphated Heparin Oligo dp8 6-O DSHO08 1mg 150.00 Enquire Now
    6-O-Desulphated Heparin Oligo dp10 6-O DSHO10 1mg 150.00 Enquire Now
    6-O-Desulphated Heparin Oligo dp12 6-O DSHO12 1mg 150.00 Enquire Now
  4. N-desulphated Heparin Oligosaccharides
    N Desulphated Heparin Oligo dp4 N DSHO04 1mg 100.00 Enquire Now
    N Desulphated Heparin Oligo dp6 N DSHO06 1mg 100.00 Enquire Now
    N Desulphated Heparin Oligo dp8 N DSHO08 1mg 100.00 Enquire Now
    N Desulphated Heparin Oligo dp10 N DSHO10 1mg 100.00 Enquire Now
    N Desulphated Heparin Oligo dp12 N DSHO12 1mg 100.00 Enquire Now
  5. N-desulphated re N-acetylated Heparin Oligosaccharides
    N-D reN-Acetylated Heparin Oligo dp4 reAc DSHO04 1mg 150.00 Enquire Now
    N-D reN-Acetylated Heparin Oligo dp6 reAc DSHO06 1mg 150.00 Enquire Now
    N-D reN-Acetylated Heparin Oligo dp8 reAc DSHO08 1mg 150.00 Enquire Now
    N-D reN-Acetylated Heparin Oligo dp10 reAc DSHO10 1mg 150.00 Enquire Now
    N-D reN-Acetylated Heparin Oligo dp12 reAc DSHO12 1mg 150.00 Enquire Now

Get a Quote

Are you interested in a product? or you need some information? Don't hesitate to get in touch.

Enquire