General formula: ∆UA,2S – (GlcNS,6S – IdoA,2S)n – GlcNS,6S
where ‘n’ is the number of disaccharide units
n = 1 in the dp4 (HO04) tetrasaccharide
n = 2 in the dp6 (HO06) hexasaccharide
n = 3 in the dp8 (HO08) octasaccharide………etc.
Uronic acid (∆UA) at the non-reducing end of the oligosaccharides has a C4-C5 double bond as a result of the endolytic action of bacterial heparinase.
Although the main disaccharide unit in these products is IdoA,2S – GlcNS,6S (approx 75%) saccharides in each size class show some variation in sulfation.
Main Heparin Disaccharide Unit